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Statins side effects: Six ‘toxic’ signs you should not ignore – you may need a lower dose

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One major risk factor for taking statins is the likelihood of developing rhabdomyolysis, which is when the muscles break down. As muscles disintegrate, they release a protein called myoglobin into the blood. In large quantities, myoglobin can damage the kidneys, the Cleveland Clinic confirmed. One key warning sign of toxicity is “unexplained muscle weakness, tenderness, or pain”, warned Medical News Today.

An individual’s tolerance to pain varies greatly from one person to the next, so it is possible early warning signs of statins toxicity is dismissed.

By the time the kidneys are struggling to function, other signs of toxicity can emerge.

For instance, upper stomach pain might occur, and this may be accompanied by “dark-coloured urine”, added Medical News Today.

Also tell your doctor if you’re experiencing a loss of appetite and you feel tired or weak.

READ MORE: Statins and alcohol: NHS issues serious warning about drinking alcohol and taking statins

Possibles causes of statin toxicity include:

  • Genetic factors
  • Medication interactions
  • Vitamin D status

The onset of type 2 diabetes has also been linked to statin treatment, but it mostly affecting patients who have pre-existing risk factors.

Pre-existing risk factors for type 2 diabetes include:

  • Elevated body mass index (BMI)
  • Impaired fasting gluocose
  • Glyctaed hemoglobin

“Neurological conditions that have been associated with statin use include hemorrhagic stroke, cognitive decline, peripheral neuropathy, depression, confusion/memory loss and aggression, and personality changes,” the researchers noted.

However, “it is unclear” whether these effects are “specific to statins per se, [or] a result of low cholesterol levels”.

The cholesterol-lowering charity, Heart UK, warned that an abrupt stop to taking statins – without medical supervision – “can lead to serious problems”.

Numerous scientific research highlights how statins protect against heart disease.

Research has shown that taking statins can reduce the risk of a heart attacks or stroke by up to 21 percent.

Do speak to your doctor about any troublesome side effects you might be experiencing.

The doctor might lower your dose, which might remedy the situation, or they may offer an alternative statin.

At present, there are five different types of statins prescribed in the UK:

  1. Atorvastatin (Lipitor)
  2. Fluvastatin (Lescol)
  3. Pravastatin (Lipostat)
  4. Rosuvastatin (Crestor)
  5. Simvastatin (Zocor)

Just because you don’t react well to one type of statin, it doesn’t mean another statin wouldn’t work better, because it could.


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